Cell‐Cell Interactions Associated with pTau Induced L2/3 Neuronal Loss in Alzheimer's Disease
Our integrative analysis of snRNA-Seq and spatial transcriptomics data highlighted critical ligand-receptor interactions with microglia and astrocyte subclusters that are associated with L2/3 neuron loss in AD. These findings underscore the complex interplay between neuronal and non-neuronal cells in AD-related neurodegeneration.
Authors
- Theodore J. Zwang (ORCID: https://orcid.org/0000-0002-6815-4482)
- Alberto Serrano‐Pozo (ORCID: https://orcid.org/0000-0003-0899-7530)
- Rachel E. Bennett (ORCID: https://orcid.org/0000-0001-9640-0575)
- Bradley T. Hyman
- Sudeshna Das
- Huan Li
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105911
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00