Cellular senescence in giant cell arteritis and polymyalgia rheumatica: From mechanisms to therapeutic opportunities
We demonstrated age-related stress and senescence in the pathogenesis of GCA and PMR. We provide an overview of senomorphics, which have shown promise in clinical trials, and emphasize the need for further research to develop effective therapies.
Authors
- Weiqian Chen (ORCID: https://orcid.org/0000-0003-3819-7841)
- Yanlin He
- Yiting Luo
- Fan Yang
- Jin Lin
Institutions
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1111/eci.70166
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China