Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Nanovesicles Alleviated Colitis via Modulating Th17/Treg Balance Through Hsa-miR-27b-3p-Mediated Suppression of PI3K/AKT/STAT3 Signaling Pathway
This study demonstrated that MSC NVs significantly alleviated DSS-induced colitis by modulating Th17/Treg balance in the colonic lamina propria, with hsa-miR-27b-3p identified as the key mediator through PIK3CA targeting and PI3K/AKT/STAT3 pathway inhibition. These findings highlight the therapeutic potential of filtration-extrusion-prepared MSC NVs as a safe and effective nanomedicine for IBD treatment.
Authors
- Ketao Jin
- Xiaoyi Chen (ORCID: https://orcid.org/0000-0001-6394-4744)
- Yuanhao Zhou (ORCID: https://orcid.org/0009-0002-8972-5288)
- Yan Zeng (ORCID: https://orcid.org/0009-0007-8082-7890)
- ZhiWei Lin
- Weijiao Fan
- xiangming Ye
- Yuanyuan Wang
- Xiaozhou Mou
- Ping Li
- Yilin Huang
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou DAC Biotech (China) (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ijn.s565416
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00