Integrated Multi‐Omic Analysis Identifies Altered Colonic Brush Border Profile as a Key Feature of Microscopic Colitis
Molecular dysregulation and aberrant ultrastructure of the colonic brush border feature the colonic epithelium in LC and CC. These previously undescribed findings provide new perspectives for further defining MC pathogenesis and identifying biomarkers for diagnosis, prognosis and treatment of this debilitating and prevalent disease.
Authors
- Fernando Fernández‐Bañares (ORCID: https://orcid.org/0000-0002-1489-504X)
- Juanjo Lozano (ORCID: https://orcid.org/0009-0001-2435-6680)
- Ronald Llerena‐Castro (ORCID: https://orcid.org/0000-0001-6860-1724)
- Julia Sidorova (ORCID: https://orcid.org/0000-0002-1024-168X)
- A Benages
- Eva Tristán (ORCID: https://orcid.org/0000-0002-9317-2447)
- Beatriz Lobo (ORCID: https://orcid.org/0000-0003-3391-7125)
- Javier E. Santos (ORCID: https://orcid.org/0000-0002-2404-3975)
- Stefania Landolfi (ORCID: https://orcid.org/0000-0002-1059-635X)
- Elba Expósito (ORCID: https://orcid.org/0000-0001-6088-3149)
- Yamile Zabana
- Joan Dot
- Maria Dolores Castillo Cejas
- Andreas Münch
- Alfredo J. Lucendo
- Danila Guagnozzi
- Ana Maria Gonzalez‐Castro
- Maria Vicario
- Carmen Alonso‐Cotoner
Institutions
- Linköping University (SE)
- Hebron University (PS)
- University Hospital Mútua de Terrassa (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Hospital General de Tomelloso (ES)
- Nestlé (Switzerland) (CH)
- Vall d'Hebron Hospital Universitari (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Linköping University Hospital (SE)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1002/ueg2.70156
- Citations
- 1
- Primary Topic
- Microscopic Colitis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- European Commission
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
- Instituto de Salud Carlos III
- European Regional Development Fund
- European Social Fund