Hypothalamic and metabolic alterations at a pre‐symptomatic stage of Alzheimer's Disease
Our results reveal early transcriptomic changes in hypothalamic endothelial cells of 3xTg-AD mice, related to immune and stress responses. Furthermore, peripheral metabolic alterations were also observed at this stage, suggesting a sex-specific effect. We propose that hypothalamic dysfunction may drive these metabolic alterations and play a key role in AD. Further analyses are underway to confirm this association using mouse and human samples.
Authors
- Karl J. L. Fernandes (ORCID: https://orcid.org/0000-0002-6236-8770)
- Marian Mayhue
- Marta Turri (ORCID: https://orcid.org/0000-0001-8293-7195)
- Anne Aumont
- Pablo Valderrama‐Carmona
- Rafael Posada‐Duque (ORCID: https://orcid.org/0000-0002-4492-3400)
- Federico Pratesi (ORCID: https://orcid.org/0000-0001-7416-9384)
- Andres Villegas‐Lanau
- Paule E.H. M'Bra
Institutions
- Université de Sherbrooke (CA)
- Universidad de Antioquia (CO)
- Q & T Research (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_103091
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00