Evolutionary Action Reveals Sex‐Specific Pathogenic and Protective Pathways and Differential Cell Involvement in Alzheimer's Disease
σ<sub>EA</sub>-Diff identifies AD genes more robustly than standard methods and predicts new high confidence candidates, including in sex-specific genes, cell types, pathways and modifiers of neurodegeneration further probing differential effects of APOE. These results point to new potential drug targets and demonstrate the power of quantitative phylogenetics in complex diseases studies.
Authors
- Olivier Lichtarge (ORCID: https://orcid.org/0000-0003-4057-7122)
Institutions
- Neurological Research Institute (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101948
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00