Alkynyl Tetracoordinate Borons Enabled Synthesis of α‐Bromo/Chloro Ketones via Sequential 1,2‐Migration and Oxidation <sup>†</sup>
Comprehensive Summary A practical and transition‐metal‐free synthesis of α‐bromo/chloro ketones is developed via sequential 1,2‐migration and oxidation of alkynyl tetracoordinate boron species under mild conditions. This method employs readily available N ‐bromosuccinimide (NBS) and N ‐chlorosuccinimide (NCS) as halogen sources, achieving high efficiency (up to 95% yield) with operational simplicity. The reaction demonstrates broad functional group tolerance, offering a versatile platform for α‐halo ketones.
Authors
- Yi Zhang (ORCID: https://orcid.org/0000-0001-7201-2092)
- Zihao Zhong (ORCID: https://orcid.org/0009-0000-7513-4861)
- Yuanbiao An
- Qiuling Song
- Yajun Yu
- Yuquan Han
- Xingxing Ma
- Ziming Chen
Institutions
- Shanghai Institute of Organic Chemistry (CN)
- Hubei Normal University (CN)
- Henan Normal University (CN)
- Fuzhou University (CN)
- Fujian University of Technology (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Chinese Journal of Chemistry
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1002/cjoc.70424
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00