A common <i>IFI44L</i> variant strongly predicts clinical trajectories in aging and neurodegeneration
A common IFI44L variant is significantly associated with clinical trajectories in normal aging and in multiple forms of neurodegenerative disease, confirming an important role for IFN signaling in aging and neurodegeneration (Figure 2).
Authors
- Patricia A. Castruita (ORCID: https://orcid.org/0009-0006-7848-5177)
- Valerie Drews Escobar
- Phuong T. Hoang (ORCID: https://orcid.org/0000-0002-1689-5043)
- J. Yokoyama
- Robert Loughnan (ORCID: https://orcid.org/0000-0003-4870-4501)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Luke W. Bonham (ORCID: https://orcid.org/0000-0002-2533-1266)
- Alexis P. Oddi (ORCID: https://orcid.org/0000-0001-9151-889X)
- Leo P. Sugrue (ORCID: https://orcid.org/0000-0001-7315-4519)
- David C. Perry (ORCID: https://orcid.org/0000-0003-3098-8593)
- Taylor P. Johnson (ORCID: https://orcid.org/0000-0001-5959-5182)
- Jared Khan (ORCID: https://orcid.org/0000-0001-5152-2907)
- Daniel W. Sirkis (ORCID: https://orcid.org/0000-0003-3440-8859)
- Yaen Chen
- Anders M. Dale (ORCID: https://orcid.org/0000-0002-6126-2966)
- Iris Broce (ORCID: https://orcid.org/0000-0003-4932-1430)
- Xin Wang (ORCID: https://orcid.org/0000-0003-0314-9268)
- B. D. Miller
- Ariel I Sauri
- Ole A. Andreassen
- Gisele Sanda
- Michael J. Corley
- William W. Seeley
Institutions
- Oslo University Hospital (NO)
- University of California, San Francisco (US)
- University of California System (US)
- University of California San Diego (US)
- University Memory and Aging Center (US)
- Global Brain Health Institute (US)
- International Neuromodulation Society (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104509
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00