Coordinated multi‐cellular responses to Alzheimer's disease pathology reveal sex‐specific resilience signatures
Multiple cell types exhibit concurrent shifts, suggesting potential multi-cellular associations with AD pathology. Changes in the first component reflected a generalized response to neurodegenerative pathology, likely representing neuronal death processes of selective neuronal subpopulations. In contrast, two additional multicellular responses emerged, suggesting sex-specific cellular activity moderating resilience to AD pathology. Coordinated cell-type-specific alterations underscore the need to address cross-cellular interactions in AD.
Authors
- Lijun An (ORCID: https://orcid.org/0000-0003-1030-4625)
- Inès Hristovska (ORCID: https://orcid.org/0000-0003-4779-4103)
- Yu Xiao (ORCID: https://orcid.org/0000-0002-7519-8248)
- Gabriele Vilkaite
- Alexa Pichet Binette
- Niklas Mattsson‐Carlgren
- Chris Gaiteri
- Jacob W. Vogel
Institutions
- Rush University Medical Center (US)
- Lund University (SE)
- SUNY Upstate Medical University (US)
- Science for Life Laboratory (SE)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Skåne University Hospital (SE)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104816
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00