Moraxella catarrhalis infection participates in Alzheimer's disease via APP coupling and Aβ production through the outer membrane protein UspA1

This study suggests that Moraxella catarrhalis contributes to AD pathogenesis through its extracellular vesicles and the UspA1 outer membrane protein, which participate in the APP proteolytic pathway and Aβ generation.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_101378
Primary Topic
Pneumonia and Respiratory Infections
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Moraxella catarrhalis infection participates in Alzheimer's disease via APP coupling and Aβ production through the outer membrane protein UspA1

Bin Jiao, Lu Shen, Jingxian Chen
Alzheimer s & Dementia
Pneumonia and Respiratory Infections
article

Moraxella catarrhalis infection participates in Alzheimer's disease via APP coupling and Aβ production through the outer membrane protein UspA1

Bin Jiao, Lu Shen, Jingxian Chen
article en

Abstract

This study suggests that Moraxella catarrhalis contributes to AD pathogenesis through its extracellular vesicles and the UspA1 outer membrane protein, which participate in the APP proteolytic pathway and Aβ generation.

Alzheimer s & DementiaVol. 21(S1)
Central South University (CN), Xiangya Hospital Central South University (CN)
Openalex Percentile: Top 30%
Pneumonia and Respiratory Infections
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Moraxella catarrhalis infection participates in Alzheimer's disease via APP coupling and Aβ production through the outer membrane protein UspA1 — Bin Jiao, Lu Shen, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS