Genetic covariance analysis identifies TMEM106B, ACE and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders
These findings support the notion of pleiotropic overlap between AD and depression, schizophrenia, anxiety respectively, and pinpoint TMEM106B, ACE, and ERC2 as shared genetic drivers. Further functional characterization of these loci, identified sequence variants, and molecular pathways will be critical to characterize the specific underlying biological processes.
Authors
- Michael Cuccaro
- Nicholas R. Ray
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Colin Stein (ORCID: https://orcid.org/0009-0005-1990-4426)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Masood Manoochehri (ORCID: https://orcid.org/0000-0001-5818-180X)
- Jiji T. Kurup (ORCID: https://orcid.org/0000-0001-6291-3911)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Alyssa N. De Vito (ORCID: https://orcid.org/0000-0002-4078-3869)
- Ajneesh Kumar (ORCID: https://orcid.org/0000-0001-5513-4135)
- Robert A. Sweet (ORCID: https://orcid.org/0000-0001-9154-9709)
- Pamela del Rosario
- Brenna Cholerton
Institutions
- University of Miami (US)
- University of Pittsburgh (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Dr. John T. Macdonald Foundation (US)
- Wake Forest University (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106714
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00