Pediatric necrotizing pneumonia caused by mixed infection with influenza A virus and Panton-Valentine Leucocidin-producing Staphylococcus aureus: case report and literature review

This study firstly documented successful treatment of three cases of severe necrotizing laryngotracheobronchitis and necrotizing pneumonia caused by PVL-positive S. aureus and IAV infection. Clinicians should raise awareness of this mixed infection in children with sudden clinical worsening after influenza to provide timely and effective treatment to decrease mortality.