Sex and APOE Genotype Differentially Modify the Association Between Hippocampal Volume and Memory Performance
While hippocampal volume is a potent predictor of memory performance, sex, and APOE modify this association with the most pronounced effects observed among APOE-ε4 carriers, women, and participants with AD. These results emphasize the importance of considering genetic, clinical, and demographic factors in AD research.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Sarah Biber
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- Haochang Shou
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Phoebe Scollard
- Alaina Durant
- Meichen Yu (ORCID: https://orcid.org/0009-0009-2228-1417)
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Li‐San Wang
- Walter W. Kukull
- Richard Mayeux
- Guray Erus
- Jonathan L Haines
- Shannon Risacher
- Paul K Crane
- Shubhabrata Mukherjee
- Abel Belachew
- Jesse Mez
- Yuhan Cui
- Margaret Pericak‐Vance
- Michael L. Lee
Institutions
- Boston University (US)
- University of Miami (US)
- Vanderbilt University (US)
- University of Washington (US)
- Columbia University Irving Medical Center (US)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104990
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00