Spatiotemporal differential regulation of extrasynaptic GluN2B receptor subunits and PSA‐NCAM in brain aging and Alzheimer's disease
Our findings demonstrate AD-specific increases in ES-GluN2B expression and a significant downregulation in PSA-NCAM levels, distinguishing AD from normal aging, potentially driven by Aβ-induced downregulation of biosynthetic enzymes ST8Sia4 and UDP-E. This underscores a potential link between PSA-NCAM expression and Aβ activity in AD, as well as possible therapeutic targets for AD intervention.
Authors
- Subhrajit Bhattacharya (ORCID: https://orcid.org/0000-0003-1326-0699)
- Jerome Garcia
- I. Rego Pérez
- Christian Crouzet (ORCID: https://orcid.org/0000-0002-8809-2119)
- Brian P. Carson (ORCID: https://orcid.org/0000-0001-8350-1481)
- Oghenetega E. Imiruaye
- Derick Han (ORCID: https://orcid.org/0000-0001-7550-0438)
Institutions
- University of California, Irvine (US)
- University of La Verne (US)
- Keck Graduate Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102267
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00