Basal forebrain cholinergic system mediates the impact of serum bile acid profiles on cognitive impairment in Alzheimer's disease
Our findings suggest that BFCS may modulate the relationship between BAs and cognitive function, with tau pathology potentially mediating the influence of BAs on BFCS. These results enhance our understanding of the intricate mechanisms through which the brain-gut axis modulates cognitive function in AD.
Authors
- Tianyi Zhang (ORCID: https://orcid.org/0000-0001-8289-3102)
- Guoping Peng
Institutions
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_101496
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00