Perivascular Spaces as Early Indicators of Alzheimer's Pathology and Cognitive Impairment in a Southeast Asian Cohort: Insights from the BIOCIS Study

This study highlights PVS burden as a marker of cerebrovascular dysfunction and amyloid-tau pathology in preclinical and prodromal AD. As a readily assessable MRI marker, PVS could enhance diagnostic frameworks by complementing cognitive screening, behavioral assessments, and existing CSVD scales. Incorporating PVS into diagnostic protocols may enable earlier and more precise identification of individuals at risk for AD. Longitudinal studies are warranted to confirm its utility as a prognostic biomarker.