Advancing PDE Inhibition: Preclinical Perspectives, Clinical Applications, and Future Therapeutics

Using PDE inhibitors as treatment continues to show promise across increasing medical applications. Although present PDEIs benefit patients we need new studies that make these inhibitors more selective for specific isoforms and with fewer unwanted effects to create improved therapeutic drugs. Emerging technology in drug discovery including artificial intelligence and personalized treatment methods will guide the creation of better and safer PDE inhibitors to treat many diseases.