Wolframin‐1–expressing neurons in the entorhinal cortex propagate tau to neocortical brain regions under the amyloid pathology influence
Our study demonstrates that APP<sup>NL-G-F</sup>:TAUKI:Wfs1-Cre mice injected with P301L tau in the ECII recapitulates advanced-stage AD pathology with amyloid beta navigating tau to the neocortical region and enhancing the maturity of tau pathology. Furthermore, ECII neuronal excitability regulates tau transfer efficiency from the ECII to CA1 region.
Authors
- Tsuneya Ikezu (ORCID: https://orcid.org/0000-0002-3979-8596)
- Brendan J. Gibbs (ORCID: https://orcid.org/0009-0001-5626-9784)
- Seiko Ikezu (ORCID: https://orcid.org/0000-0001-9879-730X)
- J. W Ellison
- Stephanie Radhakishun
- Alejandro Longtree‐Preciado
- Arun Reddy Ravula
- Ayaka Tatsumoto
- Nibedita Basu Ray
Institutions
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106794
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00