Regioselective Palladium-Catalyzed Buchwald–Hartwig Reaction of Arylhydrazines with Aryl Halides: Synthesis of <i>N</i> , <i>N</i> -Diarylhydrazines

An efficient regioselective palladium-catalyzed Buchwald-Hartwig reaction of arylhydrazines with aryl halides (including chlorides, bromides, and iodides) via C-N¹ bond formation has been successfully developed, providing a series of <i>N</i>,<i>N</i>-diarylhydrazines in moderate to excellent yields. This reaction features mild reaction conditions, the use of readily available substrates, a broad substrate scope, and a good compatibility with various functional groups. Furthermore, the total synthesis of an Ebola virus entry inhibitor was successfully achieved through a two-step process starting from the product <i>N</i>,<i>N</i>-diphenylhydrazine.