Sequential accumulation of phosphorylated tau species in early Alzheimer's disease
Our results suggest that pTau accumulation in early AD may occur in a staged manner in AD, with pTau181 accumulation in neurites being observed before other pTau species. Additionally, our proteomics results highlight the potentially important role for midkine in early AD.
Authors
- Geoffrey Pires (ORCID: https://orcid.org/0000-0002-7050-9844)
- Arline Faustin (ORCID: https://orcid.org/0000-0002-1147-9665)
- Evgeny Kanshin (ORCID: https://orcid.org/0000-0001-7142-4554)
- Aysha Y. G. Strobbe (ORCID: https://orcid.org/0009-0004-7591-8796)
- Sian Genoud
- Kaleah Balcomb (ORCID: https://orcid.org/0009-0003-7006-2776)
- Eleanor Drummond
- Beatrix Ueberheide
- Manor Askenazi
- Thomas Wisniewski
- Tomas Kavanagh
Institutions
- The University of Sydney (AU)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102149
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00