Machine Learning Analysis Reveals Distinct Neuroimaging Biomarker Patterns Across Ethnic Groups in Alzheimer's Disease

Our findings reveal distinct neuroimaging biomarker patterns across ethnic groups while highlighting the consistent importance of Tau-PET measurements. The varying model performance suggests current neuroimaging biomarkers may have different sensitivities across populations. These results emphasize the need for ethnically sensitive diagnostic approaches and warrant further investigation into population-specific AD manifestations. Future research should focus on validating these ethnic-specific biomarker patterns through longitudinal studies while considering additional factors such as genetics and social determinants of health.