Comparison of renal effect on various plasma tau assays in reference to CSF values

We confirmed the trend towards higher values associated with CKD in most plasma tau assays. While p-tau217 assays showed slightly higher AUCs and coefficient beta for AD, the high association with CSF values and possible lower association with renal dysfunction in p-tau212 may warrant further investigation in larger studies.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_096833
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparison of renal effect on various plasma tau assays in reference to CSF values

Kenji Ishibashi, Nicholas Ashton, Masanori Kurihara, Kaj Blennow et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Comparison of renal effect on various plasma tau assays in reference to CSF values

Kenji Ishibashi, Nicholas Ashton, Masanori Kurihara, Kaj Blennow, Giovanni De Santis, Atsushi Iwata, Henrik Zetterberg, Przemyslaw Radoslaw Kac, Kenji Ishii
article en

Abstract

We confirmed the trend towards higher values associated with CKD in most plasma tau assays. While p-tau217 assays showed slightly higher AUCs and coefficient beta for AD, the high association with CSF values and possible lower association with renal dysfunction in p-tau212 may warrant further investigation in larger studies.

Alzheimer s & DementiaVol. 21(S2)
Tokyo Metropolitan Institute of Gerontology (JP), University of Gothenburg (SE)
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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