A Grading System of Intratumoral Tertiary Lymphoid Structure for Combined Hepatocellular-Cholangiocarcinoma: A Multicenter Pathological Study
This novel TLS grading system effectively stratifies prognosis in cHCC-CCA, with increasing intratumoral mTLS indicating better outcomes. This practical method can be integrated into routine pathological reporting to aid clinical decision-making.
Authors
- Zhao Yun (ORCID: https://orcid.org/0000-0003-1331-3340)
- Wen‐Ming Cong (ORCID: https://orcid.org/0000-0002-8924-5551)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Miao-Xia He
- Chun-Yan Xia
- You-Wen Qian
- Hui Dong
- Xia Sheng
- Hong-Zhen Chen
Institutions
- Second Military Medical University (CN)
- Fudan University (CN)
- Huadong Hospital (CN)
- Shanghai Changzheng Hospital (CN)
- Minhang District Central Hospital (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Changhai Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jhc.s568933
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00