Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study
This two-step strategy may represent a novel therapeutic approach for the treatment of therapy-resistant PDAC through senescence induction and subsequent senolysis.
Authors
- Yuuki Shichi (ORCID: https://orcid.org/0000-0002-4655-9737)
- Toshiyuki Ishiwata (ORCID: https://orcid.org/0000-0002-4180-0069)
- Tomio Arai (ORCID: https://orcid.org/0000-0003-4583-8301)
- Yasuko Hasegawa
- Masakazu Fujiwara (ORCID: https://orcid.org/0009-0004-2734-2032)
- Koji Takahashi (ORCID: https://orcid.org/0000-0001-8134-8524)
- Hirofumi Rokutan
- Seiichi Shinji
- Keisuke Nonaka
Institutions
- Nippon Veterinary and Life Science University (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Tokyo Metropolitan Geriatric Hospital (JP)
- Nippon Medical School (JP)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-24
- DOI
- https://doi.org/10.1186/s12885-025-15317-z
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science