A mass spectrometric assay for detecting autoantibodies in cerebrospinal fluid with Data Independent Acquisition (DIA) utilizing new‐generation mass spectrometry
We optimized our method for identification of endogenous CSF autoantibodies on various mass spectrometric platforms using an internal antibody control that assures optimal performance of all experimental runs. We believe that this assay will be instrumental in identifying novel autoantibodies that may be related to AD pathogenesis.
Authors
- Miyo K. Chatanaka (ORCID: https://orcid.org/0000-0002-5864-8315)
- Cassandra Wong
- Eleftherios P. Diamandis (ORCID: https://orcid.org/0000-0002-1589-820X)
- Antoninus Soosaipillai
Institutions
- University of Toronto (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Sinai Health System (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_096828
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00