Complement gene expression profiles are altered in the AD frontal cortex
Our comprehensive complement expression atlas for the AD and control frontal cortex reveals profound complement dysregulation in AD. There are sex specific trends in this dysregulation with females demonstrating greater dysregulation. Finally, most severe complement dysregulation in AD is observed in the youngest individuals highlighting a significant age-dependent factor that could inform the timing and design of therapeutic interventions.
Authors
- Wioleta M. Zelek (ORCID: https://orcid.org/0000-0002-2230-3550)
- B. Paul Morgan (ORCID: https://orcid.org/0000-0003-4075-7676)
- Matthew Thomas Bright
- Van Dien Nguyen
Institutions
- UK Dementia Research Institute (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_100157
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00