Fine‐mapping of the TMEM106B locus reveals four haplotypes that are differentially associated with risk for neurodegeneration
Our data indicates that the genetic structure underlying the association of the TMEM106B locus with neurodegenerative diseases is driven by the effect of multiple haplotypes.
Authors
- Lydian Knoop
- August Benjamin Smit (ORCID: https://orcid.org/0000-0002-2286-1587)
- Marcel J.T. Reinders
- Jana Křížová (ORCID: https://orcid.org/0000-0003-1841-7341)
- Alex Salazar (ORCID: https://orcid.org/0000-0002-8453-8769)
- Sanduni Wijesekera
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Henne Holstege
- Marc Hulsman
- Mikko Hiltunen
- Markus Damme
- Leonard Petrucelli
- Sven J van der Lee
Institutions
- University of Eastern Finland (FI)
- WinnMed (US)
- Christian-Albrechts-Universität zu Kiel (DE)
- Amsterdam Neuroscience (NL)
- Mayo Clinic in Florida (US)
- Amsterdam University Medical Centers (NL)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Vrije Universiteit Amsterdam (NL)
- Delft University of Technology (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104407
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00