Single‐nuclei sequencing in ovariectomized rat hippocampus identifies estrogen‐sensitive brain cell sub‐populations and pathways

These findings extend previous reports of estrogen loss affecting bioenergetics, specifically oxidative phosphorylation, as well as neuroinflammation and synaptic function. Ongoing studies aim to identify further cell-type specific pathway contributions. Outcomes will advance an understanding of brain cell-specific responses to estrogen loss and help identify specific drivers of brain vulnerability in the estrogen-deficient female brain.