Micro‐sub regional synapse weakening by mimicking the hyperphosphorylation of microtubule associated protein Tau in dendritic spines

Here, we illustrate, that Tau-PHF1E, a human tau phosphomimic construct, exhibited a spatially distribution of pathophysiology, with the distal dendric regions of stratum radiatum exhibiting dysfunction while the proximal region of the same dendrites remained unaffected. Furthermore, we observed that these deficits were dependent upon the presence of a key tau interacting protein; protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1).