Sex moderates the association between medial temporal tau pathology and cognitive decline: A multi‐cohort study
Among those with higher medial temporal tau, women exhibit faster cognitive decline compared to men. These findings suggest that early intervention with anti-tau therapies may be particularly important for women who exhibit medial temporal tauopathy. Future research should investigate sex differences in the spread of medial temporal tau to the neocortex, which may further elucidate faster cognitive decline among women.
Authors
- Oliver Langford (ORCID: https://orcid.org/0009-0006-8951-1326)
- Aaron P. Schultz (ORCID: https://orcid.org/0000-0002-0418-0999)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Michael Donohue (ORCID: https://orcid.org/0000-0001-6026-2238)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Erin M. Jonaitis (ORCID: https://orcid.org/0009-0004-5091-8255)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Colin Birkenbihl (ORCID: https://orcid.org/0000-0002-7212-7700)
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Hannah M Klinger
- Annie Li (ORCID: https://orcid.org/0009-0005-7020-5794)
- K. A. Johnson
- REMA RAMAN (ORCID: https://orcid.org/0000-0002-4096-6390)
- R. Sperling
- Hyun‐Sik Yang
- Sterling C Johnson
- Rebecca E. Langhough
- Dorene M. Rentz
- Michelle E. Farrell
- Michael J. Properzi
- Mabel Seto
- Diana L Townsend
- Kathryn V Papp
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- The University of Melbourne (AU)
- Massachusetts General Hospital (US)
- Wisconsin Division of Public Health (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100370
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47