Microglial Activation and Tau Accumulation in the Alzheimer's Disease Spectrum: Insights from Longitudinal PET Imaging
These findings suggest microglial activation increases in ADS and correlates inversely with TAU, with spatial and temporal patterns supporting a mild pseudotemporal precedence of microglial activation over tau accumulation.
Authors
- Lena‐Katharina Trappmann
- Oliver Pogarell (ORCID: https://orcid.org/0000-0001-6455-4190)
- Florian Eckenweber
- Maia Tatò
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Endy Weidinger (ORCID: https://orcid.org/0009-0003-6679-7788)
- Oliver Goldhardt (ORCID: https://orcid.org/0000-0002-3841-3391)
- Boris Papazov (ORCID: https://orcid.org/0000-0002-5274-9166)
- Selim Guersel
- Boris‐Stephan Rauchmann (ORCID: https://orcid.org/0000-0003-4547-6240)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Carla Palleis (ORCID: https://orcid.org/0000-0002-4331-8145)
- Gloria Biechele (ORCID: https://orcid.org/0009-0008-5161-9571)
- Lena Burow
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Estrella Morenas‐Rodríguez (ORCID: https://orcid.org/0000-0002-7591-6051)
- Marco Öchsner (ORCID: https://orcid.org/0000-0002-2214-3315)
- Jan Haeckert (ORCID: https://orcid.org/0000-0002-4319-5034)
- Sebastian Schuster (ORCID: https://orcid.org/0009-0009-8486-5581)
- Carolin Kurz (ORCID: https://orcid.org/0000-0003-4299-6240)
- Daniel Janowitz (ORCID: https://orcid.org/0009-0003-4090-547X)
- R. Rupprecht
- Mirlind Zaganjori (ORCID: https://orcid.org/0009-0000-5740-4549)
- Anika Finze (ORCID: https://orcid.org/0000-0002-3966-5814)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Julia Utecht
- Sophia Stöcklein
- Ersin Ersözlü
- Daniel Keeser
- Matthias Brendel
- Günter U Höglinger
- Timo Grimmer
- Michael Ewers
- Olaf Dietrich
- Axel Rominger
- Peter Bartenstein
Institutions
- University Hospital of Bern (CH)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- München Klinik (DE)
- Klinik und Poliklinik für Psychiatrie und Psychotherapie (DE)
- University of Regensburg (DE)
- Technical University of Munich (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Sheffield (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101228
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00