Investigating the Possible Contributions of nsSNPs in ADAM10 and ADAM17 to Alzheimer's Disease Progression: An in Silico Analysis

The analysis highlights the presence of variants with high pathogenicity scores, suggesting their significant role in disease mechanisms. This study identifies potentially pathogenic nsSNPs in ADAM10 and ADAM17 that may affect their alpha-secretase activity and contribute to AD pathogenesis. Further experimental validation is essential to confirm these results and clarify their roles in disease mechanisms.