The interplay between sex, ApoE, and insomnia in Alzheimer's disease pathogenesis

There are many factors that increase an individual's risk for developing AD, including insomnia, sex, and ApoE genotype. Here we have identified a pathway that may contribute to the interplay among these factors in AD pathogenesis. This study could facilitate a better understanding of sex- and ApoE-specific treatment responsiveness, which guide future precision-medicine guided therapeutic development in AD.