Unveiling FAD <sup>3T</sup> : A Groundbreaking Transgenic Mouse Model for Accelerating Alzheimer's Disease Research
Our findings highlight the exceptional fidelity of the FAD<sup>3T</sup> model in recapitulating the complex etiology of AD. Compared to traditional AD mouse models, FAD<sup>3T</sup> exhibits accelerated disease onset and progression, providing a rapid platform for expediting drug testing cycles, particularly for therapies targeting disease progression. This innovative mouse model represents a transformative tool for enhancing our understanding of AD pathophysiology and facilitating the expedited development of therapeutic strategies.
Authors
- Bingzhou Han
- Tao Wang
- Rui Feng
- Ziying Lai
- Xiang Gao
Institutions
- Key Laboratory of Guangdong Province (CN)
- Geological Exploration Technology Institute of Jiangsu Province (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_102567
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00