Designing and evaluation of mupirocin-bFGF co-loaded biodegradable antimicrobial gelatin-chitosan sponge for topical wound management in rat model

The Developed sponge was found with satisfactory water uptake capacity (76.96 ± 0.79%), porosity (71.64 ± 0.7), and folding endurance (251.33 ± 4.33%), and was completely digested. Microscopy confirms the internal porous structure. Drug loading and entrapment efficiency of the final formulation were found to be 1.859 ± 0.024% and 92.95 ± 1.09%, respectively. The formulation releases 88.018 ± 3.12% mupirocin in 5 hours and best fitted in the Korsmeyer-Peppas kinetic model with a non-Fickian transport mechanism. Antimicrobial studies show a zone of inhibition of 37±2.65 mm. The wound healing study and histological studies of the formulation showed accelerated wound contraction and healing efficacy.