Distinct early cortical thickness patterns in heterozygous APOE3‐Christchurch carriers and age‐matched controls
Heterozygous APOE3<sup>Ch</sup> carriers demonstrate distinct early CT patterns, characterized by increased thickness in fronto-parietal regions. These areas have been associated with enhanced cognitive reserve and may play a role in delaying the onset of AD. These findings suggest that structural differences in specific brain regions may contribute to the protective effects observed in APOE3<sup>Ch</sup> carriers. Future research incorporating multimodal brain imaging could help us uncover the mechanisms driving AD resistance in these individuals.
Authors
- Yamile Bocanegra (ORCID: https://orcid.org/0000-0003-3064-2509)
- Justin S. Sanchez (ORCID: https://orcid.org/0000-0003-4421-3078)
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Diego Sepúlveda‐Falla (ORCID: https://orcid.org/0000-0003-0176-2042)
- Irina Gonzalez (ORCID: https://orcid.org/0000-0003-4570-1313)
- Catarina Tristão‐Pereira (ORCID: https://orcid.org/0000-0001-9660-8341)
- Vincent Malotaux (ORCID: https://orcid.org/0000-0003-0737-9220)
- Claudia Cristina Araújo Muñoz
- Lucía Madrigal (ORCID: https://orcid.org/0000-0003-0241-4947)
- Diana Alzate
- Sergio Castro Álvarez
- Díaz Vásquez
- David Fernando Aguillón Niño (ORCID: https://orcid.org/0000-0003-2283-536X)
- Joseph F Arboleda‐Velasquez
- Clara Vila‐Castelar
- Liliana A Ramirez Gomez
- Lusiana Martinez
- Bing He
- Averi Giudicessi
Institutions
- Boston University (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Universität Hamburg (DE)
- Washington University in St. Louis (US)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Hospital Pablo Tobon Uribe (CO)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_097335
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00