Higher blood pituitary adenylate cyclase‐activating polypeptide levels were causally associated with a decreased risk of Alzheimer's disease

The present MR study demonstrates that blood PACAP levels causally contribute to lower susceptibility to AD, suggesting that PACAP might serve as a potential target for diagnosis or therapy of AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_096870
Primary Topic
Neuropeptides and Animal Physiology
Type
article
Field-Weighted Citation Impact
0.00
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article

Higher blood pituitary adenylate cyclase‐activating polypeptide levels were causally associated with a decreased risk of Alzheimer's disease

Rui Li, Xingzhi Guo
Alzheimer s & Dementia
Neuropeptides and Animal Physiology
article

Higher blood pituitary adenylate cyclase‐activating polypeptide levels were causally associated with a decreased risk of Alzheimer's disease

Rui Li, Xingzhi Guo
article en

Abstract

The present MR study demonstrates that blood PACAP levels causally contribute to lower susceptibility to AD, suggesting that PACAP might serve as a potential target for diagnosis or therapy of AD.

Alzheimer s & DementiaVol. 21(S2)
Shanxi Medical University (CN), Shaanxi Provincial People's Hospital (CN), Shanxi Provincial People’s Hospital (CN)
Openalex Percentile: Top 38%
Neuropeptides and Animal Physiology
DOIOpen Access PDFOpenAlex
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