Influence of PLEK Genetic Variants on Brain Glucose Metabolism
The PLEK gene encodes pleckstrin, a plasma protein involved in the innate immune response and expressed in glial cells. Variants of PLEK associated with FDG-PET imaging suggest a potential link between a plasma protein related to immune cells and brain glucose metabolism. To our knowledge, the role of PLEK in brain glucose metabolism has not been previously reported. Therefore, future studies should explore these associations to better understand the underlying mechanisms and their implications for AD pathology.
Authors
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Christian Limberger (ORCID: https://orcid.org/0000-0002-5160-3886)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- Débora Guerini de Souza (ORCID: https://orcid.org/0000-0003-2982-4989)
- Guilherme Povala
- Eduardo R. Zimmer
- Marco De Bastiani
- Pedro Rosa‐Neto
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- University of Pittsburgh (US)
- Instituto do Cérebro (BR)
- McGill University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104281
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00