Examining the Role of <i>SORL1</i> in Driving Alzheimer's Disease‐Related Alterations in Endolysosomal Trafficking in Neurons and Microglia
Our findings suggest that the SORL1 C1431fs deletion is capable of inducing defects in endolysosomal trafficking in both neurons and microglia. Ongoing studies in SORL1<sup>+/C1431fs</sup> microglia and neurons will further expand our understanding of SORL1's role in regulating endolysosomal phenotypes across multiple cell types implicated in AD.
Authors
- Michael Cuccaro
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Jeffery M. M Vance
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- Peter St George‐Hyslop (ORCID: https://orcid.org/0000-0003-0796-7209)
- C. Golightly (ORCID: https://orcid.org/0000-0001-6256-9153)
- Lauren Coombs
- Lauren E. Rothschild
- Margaret Pericak‐Vance
- Yalun Zhang
- Brian W Kunkle
Institutions
- University of Miami (US)
- University of Toronto (CA)
- Dr. John T. Macdonald Foundation (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105337
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00