Potential neuroprotective effect of sertraline and mirtazapine on neuronal exposure to oxidative stress, amyloid beta and hypoxia
Our preliminary results suggest that sertraline and mirtazapine may reduce dementia risk, possibly by reducing Aβ mitochondrial toxicity or Aβ mediated excitotoxicity.
Authors
- Mizuki Morisaki (ORCID: https://orcid.org/0000-0002-6741-9370)
- Robert A. Fisher (ORCID: https://orcid.org/0000-0002-0387-290X)
- Robert A. MacLachlan (ORCID: https://orcid.org/0000-0001-5995-5854)
- Lindsey I. Sinclair (ORCID: https://orcid.org/0000-0002-4776-4118)
- Lucy Crompton (ORCID: https://orcid.org/0000-0002-2642-1183)
- Oliver Milner (ORCID: https://orcid.org/0000-0002-4625-1484)
- W. E. Watts
- Daniel J Whitcomb
Institutions
- University of the West of England (GB)
- University of Bristol (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_104358
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00