Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant Surfaces

A stimuli-responsive drug delivery coating is proposed for titanium (Ti) implants to locally treat infectious and peri-implant inflammatory diseases. The system integrates a pH-responsive film based on poly(methacrylic acid) (PMAA) film over a layer-by-layer (LbL) drug delivery platform containing tetracycline (TC) complexed with anionic beta cyclodextrin (βCD). This smart coating was designed to control drug release, maintain antimicrobial activity against biofilm-forming pathogens, and enhance soft tissue sealing at the implant interface. The coating effectively regulated drug release, exhibited favorable hydrophilicity, and reduced surface roughness compared with untreated Ti surfaces. Cytocompatibility was confirmed in both monolayer cell cultures and collagen matrix environments, with no cytotoxic effects observed up to 6 days. Atomic force microscopy (AFM) revealed enhanced interactions between the PMAA film and cellular components, as evidenced by filopodial projections at the cell margins. The coating's antibacterial properties were validated using human saliva-derived biofilms, demonstrating broad-spectrum antimicrobial activity against pathogens typically involved in dental implant infections. <i>In vivo</i>, a rat subcutaneous tissue model was used to evaluate the immune response. The LbL/TCβCD/PMAA coating significantly reduced inflammation, increased collagen deposition, and elevated CD206 expression, indicating a shift toward an anti-inflammatory and tissue-repair phenotype. This stimuli-responsive coating represents a promising strategy for localized infection control, drug delivery, and soft tissue integration on implant surfaces.

Authors

Institutions

Publication Details

Journal
ACS Applied Materials & Interfaces
Published
2025-12-23
DOI
https://doi.org/10.1021/acsami.5c19344
Citations
2
Primary Topic
Bone Tissue Engineering Materials
Type
article
Field-Weighted Citation Impact
1.35
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant Surfaces

Marta Maria Alves Pereira, Ana Cláudia Pavarina, Oya Tagit, Abhijna Das et al.
2 citations
ACS Applied Materials & Interfaces
Bone Tissue Engineering Materials
1.35
article

Targeted Infection Control and Tissue Integration via pH-Sensitive Smart Coatings on Implant Surfaces

Marta Maria Alves Pereira, Ana Cláudia Pavarina, Oya Tagit, Abhijna Das, Cleyton Alexandre Biffe, Magda Feres, Edilson Ervolino, Paula Aboud Barbugli, Belén Retamal‐Valdes, Vinícius Franzão Ganzaroli, Rodolfo Debone Piazza, Érica Dorigatti de Ávila, Valentim Adelino Ricardo Barão, Amanda Paino Santana, Daniela Leal Zandim-Barcelos, Jeroen J.J.P. van den Beucken, Beatriz Severino Verza, Stéfany Barbosa Alves da Cruz, Rafael Scaf de Molon, Rodrigo Fernando Costa Marques, Denise Madalena Palomari Spolidorio, Leonardo Perez Faverani
article en
2 citations

Abstract

A stimuli-responsive drug delivery coating is proposed for titanium (Ti) implants to locally treat infectious and peri-implant inflammatory diseases. The system integrates a pH-responsive film based on poly(methacrylic acid) (PMAA) film over a layer-by-layer (LbL) drug delivery platform containing tetracycline (TC) complexed with anionic beta cyclodextrin (βCD). This smart coating was designed to control drug release, maintain antimicrobial activity against biofilm-forming pathogens, and enhance soft tissue sealing at the implant interface. The coating effectively regulated drug release, exhibited favorable hydrophilicity, and reduced surface roughness compared with untreated Ti surfaces. Cytocompatibility was confirmed in both monolayer cell cultures and collagen matrix environments, with no cytotoxic effects observed up to 6 days. Atomic force microscopy (AFM) revealed enhanced interactions between the PMAA film and cellular components, as evidenced by filopodial projections at the cell margins. The coating's antibacterial properties were validated using human saliva-derived biofilms, demonstrating broad-spectrum antimicrobial activity against pathogens typically involved in dental implant infections. <i>In vivo</i>, a rat subcutaneous tissue model was used to evaluate the immune response. The LbL/TCβCD/PMAA coating significantly reduced inflammation, increased collagen deposition, and elevated CD206 expression, indicating a shift toward an anti-inflammatory and tissue-repair phenotype. This stimuli-responsive coating represents a promising strategy for localized infection control, drug delivery, and soft tissue integration on implant surfaces.

ACS Applied Materials & InterfacesVol. 18(1)
Harvard University (US), Radboud University Nijmegen (NL), Universidade Estadual de Campinas (UNICAMP) (BR), University of Dental Medicine (MM), FHNW University of Applied Sciences and Arts Northwestern Switzerland (CH), Universidade Federal do Piauí (BR), Naval Postgraduate School (US), Bioanalytica (Switzerland) (CH), Methodist University of Piracicaba (BR), Institute for Postgraduate Medical Education (CZ), Centre de Recherche en Sciences et Technologies de l'Information et de la Communication (FR), Consultative and Diagnostic Center (RU), Postgraduate Center for Mental Health (US), Institute of Inorganic Chemistry of the Slovak Academy of Sciences (SK), Institute for Diagnosis and Animal Health (RO), Instituto de Saúde (BR), Tashkent Institute Of Postgraduate Medical Education (UZ), DNA Diagnostic (Denmark) (DK), Brazilian Center for Research in Energy and Materials (BR), Office of Basic Energy Sciences (US), Institute of Infection and Immunity (CA), Laboratório Nacional de Nanotecnologia, Universidade Estadual Paulista (Unesp) (BR)
Good health and well-being
Openalex Percentile: Top 16%
Bone Tissue Engineering Materials
1.35
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.