Reduced cholinergic tone and hippocampal‐dependent cognitive impairments in APP <sup>NL‐F</sup> mice
These findings highlight the role of early deficits in cholinergic synaptic function associated with spatial memory impairments before overt pathology in APP<sup>NL-F</sup> mice. Future experiments aim to develop strategies to rescue memory and cholinergic tone dysfunction.
Authors
- Vânia F. Prado (ORCID: https://orcid.org/0000-0003-4994-6393)
- Alycia M Crooks (ORCID: https://orcid.org/0000-0002-9702-3780)
- Timothy J. Bussey (ORCID: https://orcid.org/0000-0002-3180-3709)
- Lisa M Saksida
- Taylor W. Schmitz
- Marco AM Prado
- Kate M. Onuska
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Robarts Clinical Trials (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107535
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00