Susceptibility to Penicillin G and Ceftriaxone in Three Clinical Treponema pallidum Isolates is not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein

We demonstrated no differences in susceptibility to penicillin G and ceftriaxone in three modern T. pallidum isolates (UW244B, UW249B, and UW330B), each carrying a variant of the penicillin-binding protein (PBP) Tp0705. This suggests that these polymorphisms should not be a reason for concern when β-lactams are prescribed for syphilis treatment.

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Publication Details

Journal
Sexually Transmitted Diseases
Published
2025-12-24
DOI
https://doi.org/10.1097/olq.0000000000002291
Primary Topic
Syphilis Diagnosis and Treatment
Type
article
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article

Susceptibility to Penicillin G and Ceftriaxone in Three Clinical Treponema pallidum Isolates is not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein

Lauren C. Tantalo, Lorenzo Giacani, Kathyani D. Chamakuri, Nicole A.P. Lieberman et al.
Sexually Transmitted Diseases
Syphilis Diagnosis and Treatment
article

Susceptibility to Penicillin G and Ceftriaxone in Three Clinical Treponema pallidum Isolates is not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein

Lauren C. Tantalo, Lorenzo Giacani, Kathyani D. Chamakuri, Nicole A.P. Lieberman, Alexander L. Greninger
article en

Abstract

We demonstrated no differences in susceptibility to penicillin G and ceftriaxone in three modern T. pallidum isolates (UW244B, UW249B, and UW330B), each carrying a variant of the penicillin-binding protein (PBP) Tp0705. This suggests that these polymorphisms should not be a reason for concern when β-lactams are prescribed for syphilis treatment.

Sexually Transmitted Diseases
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), University of Washington (US), Fred Hutch Cancer Center (US), Public Works (GB)
Openalex Percentile: Top 34%
Syphilis Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Susceptibility to Penicillin G and Ceftriaxone in Three Clinical Treponema pallidum Isolates is not Altered by Amino Acid Polymorphisms in the Tp0705 Penicillin Binding Protein — Lauren C. Tantalo, Lorenzo Giacani, et al. · Sexually Transmitted Diseases (2025) | TGRS Research Map | TGRS