Associations between classical Alzheimer’s Disease biomarkers and key proteins defining potential pathophysiological mechanisms – A multi‐analyte proteomic analysis

AD-specific proteins are moderately to strongly correlated with each other on the Alamar platform. The most significantly associated proteins with ATN & I biomarkers within the platform included markers subserving inflammation, connective tissue integrity, and vascular function. Follow up studies should be longitudinal with individuals across the AD continuum.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70862_109869
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Associations between classical Alzheimer’s Disease biomarkers and key proteins defining potential pathophysiological mechanisms – A multi‐analyte proteomic analysis

Hubert Leo, Omonigho M. Bubu, Joshua L. Gills
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Associations between classical Alzheimer’s Disease biomarkers and key proteins defining potential pathophysiological mechanisms – A multi‐analyte proteomic analysis

Hubert Leo, Omonigho M. Bubu, Joshua L. Gills
article en

Abstract

AD-specific proteins are moderately to strongly correlated with each other on the Alamar platform. The most significantly associated proteins with ATN & I biomarkers within the platform included markers subserving inflammation, connective tissue integrity, and vascular function. Follow up studies should be longitudinal with individuals across the AD continuum.

Alzheimer s & DementiaVol. 21(S8)
NYU Langone Health (US), New York University (US)
Openalex Percentile: Top 34%
Alzheimer's disease research and treatments
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.