Nano‐space Video‐imaging reveals Action of ADUCANUMAB to Amyloid β aggregates: The Comparison with the Action of LECANEMAB

Aducanumab bound to spherical and curvilinear oligomers (protofibrils) and to fibrils. However, the amount of aducanumab bound to protofibrils was significantly lower than the amount bound to lecanemab. In addition, consistent with previous study results (DOI: 10.1038/s41594-020-0505-6), aducanumab binding to fibrils did not significantly inhibit fibril elongation. However, we found that aducanumab promoted the formation of larger spherical oligomers in the seeding reaction, suggesting that the formation of larger oligomers may contribute to the inhibition of secondary nucleation.