A comparison of four fully automated platforms for the measurement of plasma <i>p</i> ‐tau217 in the Alzheimer’s disease continuum
Fully automated immunoassays are essential for the widespread adoption of p -tau217, but they must uphold high diagnostic performances previously shown and recommended<sup>2</sup>. This study demonstrates four fully automated RUO assays exhibit comparable and desirable diagnostic accuracy for amyloid PET positivity. Further results will present findings from the full cohort (n =5,574), compare assays in terms of longitudinal change and relation to neuropathological change at post-mortem.
Authors
- Tainá M. Marques (ORCID: https://orcid.org/0000-0001-6098-2817)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Zivjena Vucetic (ORCID: https://orcid.org/0000-0002-9942-0202)
- Rachael E. Wilson (ORCID: https://orcid.org/0000-0003-4197-7777)
- Kinal Bhatt (ORCID: https://orcid.org/0000-0003-0261-9643)
- EM Reiman
- Arejas J. Uzgiris (ORCID: https://orcid.org/0000-0002-3394-9787)
- Jessica B. Langbaum (ORCID: https://orcid.org/0000-0003-3848-1324)
- Corey M. Carlson
- Ramiro Eduardo Rea Reyes (ORCID: https://orcid.org/0000-0001-9749-282X)
- Marisa N. Denkinger (ORCID: https://orcid.org/0000-0002-3696-3795)
- R. A. Sperling
- A. Atri
- KA Johnson
- Maria‐Magdalena Patru
- Eddine Merabet
- Valentina Ghisays
- Paul S. Aisen
- Geidy E Serrano
- Alpana Singh
- Kari Dieckhoff
- James Liu
- Elizabeth Head
- Antoine Leuzy
- Robert C. Alexander
- Thomas G. Beach
- Sterling C. Johnson
Institutions
- University of Southern California (US)
- Brigham and Women's Hospital (US)
- Roche (United States) (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of California, Irvine (US)
- Massachusetts General Hospital (US)
- Banner Sun Health Research Institute (US)
- Beckman Coulter Foundation (US)
- Siemens Healthcare (United States) (US)
- Banner Alzheimer’s Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108882
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00