Parental history of memory impairment predicts tau‐PET accumulation in a preclinical population
This is one of the first studies of parental history and longitudinal AD endophenotypes in a large sample of cognitively unimpaired individuals. Our findings that participant-reported history of paternal history is associated with faster tau accumulation stands at odds with evidence suggesting greater risk of maternal history of dementia. However, a recent study by Ourry et al., also highlights a relationship between paternal history and tau. These findings could be driven by biological or survival bias differences in the sample and deserves further exploration.
Authors
- Aaron P. Schultz (ORCID: https://orcid.org/0000-0002-0418-0999)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Rachel F. Buckley (ORCID: https://orcid.org/0000-0002-5356-5537)
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Colin Birkenbihl (ORCID: https://orcid.org/0000-0002-7212-7700)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- D. Rentz
- Hannah M Klinger
- Kathryn Papp
- KA Johnson
- Hyun‐Sik Yang
- Reisa A. Sperling
- Mabel Seto
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108687
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00