Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance
- Establishment of catalytic deficient BVRA mouse mutants;- Anti-malarial effect of BVRA relies on its catalytic activity;- A minimal bilirubin threshold for parasite control;- A minimal bilirubin threshold for malaria resolution.
Authors
- Bindu D. Paul (ORCID: https://orcid.org/0000-0002-1862-6103)
- Miguel Mesquita (ORCID: https://orcid.org/0000-0001-5927-790X)
- Sílvia Cardoso (ORCID: https://orcid.org/0000-0003-4639-698X)
- Sara Pagnotta (ORCID: https://orcid.org/0000-0002-0931-8942)
- Elisa Jentho (ORCID: https://orcid.org/0000-0002-4790-7860)
- Ana Nóvoa (ORCID: https://orcid.org/0000-0002-5668-5630)
- Ana Sofia Figueiredo (ORCID: https://orcid.org/0000-0002-2575-2191)
- Susana Ramos (ORCID: https://orcid.org/0000-0001-6356-1065)
- Moises Mallo
- Miguel Che Parreira Soares
- Sharad Rastogi (ORCID: https://orcid.org/0000-0002-2333-7170)
- Ana Rita Carlos
Institutions
- University of Lisbon (PT)
- Johns Hopkins University (US)
- Instituto Gulbenkian de Ciência (PT)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-22
- DOI
- https://doi.org/10.64898/2025.12.19.694840
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- Johns Hopkins University
- “la Caixa” Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Horizon 2020 Framework Programme
- National Institute on Aging