The whereabouts of presenilins: from location to mechanisms

Our data revealed new insights in how PSEN2/γ-secretase may regulate LE/Lys homeostasis, providing novel starting points to better understand the etiology of endolysosomal dysfunctions as observed at early, preclinical stages of AD. Notably, specific FAD-mutations also re-locate PSEN1/γ-secretase to LE/Lys, underscoring that knowledge gained here could aid to understand the more heterogeneous PSEN1 mutations.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_098886
Primary Topic
Cellular transport and secretion
Type
article
Field-Weighted Citation Impact
0.00
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article

The whereabouts of presenilins: from location to mechanisms

WIM ANNAERT
Alzheimer s & Dementia
Cellular transport and secretion
article

The whereabouts of presenilins: from location to mechanisms

WIM ANNAERT
article en

Abstract

Our data revealed new insights in how PSEN2/γ-secretase may regulate LE/Lys homeostasis, providing novel starting points to better understand the etiology of endolysosomal dysfunctions as observed at early, preclinical stages of AD. Notably, specific FAD-mutations also re-locate PSEN1/γ-secretase to LE/Lys, underscoring that knowledge gained here could aid to understand the more heterogeneous PSEN1 mutations.

Alzheimer s & DementiaVol. 21(S1)
VIB-KU Leuven Center for Brain & Disease Research (BE)
Openalex Percentile: Top 34%
Cellular transport and secretion
DOIOpen Access PDFOpenAlex
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The whereabouts of presenilins: from location to mechanisms — WIM ANNAERT · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS