Ginsenoside Rb1 attenuates arterial aging by reducing DNA damage in aged mice
This study demonstrates that Rb1 attenuates DNA damage, thus ameliorating structural remodeling and biomechanical function of the aging aorta, and delaying vascular aging and apoptosis. Our findings suggest that Rb1 counteracts age-related aortic impairment, potentially by targeting the DNA damage pathway, which highlights its therapeutic potential against vascular aging.
Authors
- Jianrui Zheng
- Lin Wu
- Xiaoxian Qian
- Bin Zhou
- Baoshun Hao
- Yanling Zhang
- Ximei Zhang
- Qi Si
- Yong Liu
- Shujie Yu
- Guangyao Shi
- Yingying Zhao
- Dinghui Liu
Institutions
- Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1016/j.exger.2025.113011
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00